Clinical and microbiological characteristics of adult invasive Haemophilus influenzae infections: results of a 14-year single-center experience from Hungary

Infection. 2018 Dec;46(6):855-860. doi: 10.1007/s15010-018-1213-6. Epub 2018 Sep 6.

Abstract

To describe the characteristics of adult invasive H. influenzae disease, 34 patients diagnosed at a single tertiary center between 2004 and 2017 were analyzed in a retrospective case series study. The annual estimated incidence was 0.1 cases/100.000 inhabitants. Dominant source of infection was pneumonia accompanied by sepsis (62%) and caused by nontypeable strains (74%) with low ampicillin resistance (14%). Survival (94%) and complication rates were high (35%). Main empirical treatments were ceftriaxone or levofloxacine.

Keywords: Adult disease; Haemophilus influenzae; Hungary; Invasive disease.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Ampicillin / therapeutic use
  • Anti-Bacterial Agents / therapeutic use*
  • Ceftriaxone / therapeutic use
  • Drug Resistance, Bacterial*
  • Female
  • Haemophilus Infections / complications
  • Haemophilus Infections / diagnosis
  • Haemophilus Infections / epidemiology*
  • Haemophilus Infections / microbiology
  • Haemophilus influenzae / drug effects
  • Haemophilus influenzae / physiology*
  • Humans
  • Hungary / epidemiology
  • Incidence
  • Levofloxacin / therapeutic use
  • Male
  • Middle Aged
  • Retrospective Studies
  • Sepsis / diagnosis
  • Sepsis / epidemiology*
  • Sepsis / microbiology

Substances

  • Anti-Bacterial Agents
  • Levofloxacin
  • Ceftriaxone
  • Ampicillin