Abstract
To describe the characteristics of adult invasive H. influenzae disease, 34 patients diagnosed at a single tertiary center between 2004 and 2017 were analyzed in a retrospective case series study. The annual estimated incidence was 0.1 cases/100.000 inhabitants. Dominant source of infection was pneumonia accompanied by sepsis (62%) and caused by nontypeable strains (74%) with low ampicillin resistance (14%). Survival (94%) and complication rates were high (35%). Main empirical treatments were ceftriaxone or levofloxacine.
Keywords:
Adult disease; Haemophilus influenzae; Hungary; Invasive disease.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Ampicillin / therapeutic use
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Anti-Bacterial Agents / therapeutic use*
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Ceftriaxone / therapeutic use
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Drug Resistance, Bacterial*
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Female
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Haemophilus Infections / complications
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Haemophilus Infections / diagnosis
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Haemophilus Infections / epidemiology*
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Haemophilus Infections / microbiology
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Haemophilus influenzae / drug effects
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Haemophilus influenzae / physiology*
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Humans
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Hungary / epidemiology
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Incidence
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Levofloxacin / therapeutic use
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Male
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Middle Aged
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Retrospective Studies
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Sepsis / diagnosis
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Sepsis / epidemiology*
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Sepsis / microbiology
Substances
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Anti-Bacterial Agents
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Levofloxacin
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Ceftriaxone
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Ampicillin