Updates in Effusion Cytology

Christin M Lepus; Marina Vivero

doi:10.1016/j.path.2018.05.003

Updates in Effusion Cytology

Surg Pathol Clin. 2018 Sep;11(3):523-544. doi: 10.1016/j.path.2018.05.003.

Authors

Christin M Lepus¹, Marina Vivero²

Affiliations

¹ Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
² Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Electronic address: mvivero@bwh.harvard.edu.

PMID: 30190139
DOI: 10.1016/j.path.2018.05.003

Abstract

Effusion cytology plays multiple roles in the management of benign and malignant disease, from primary diagnosis to tissue allocation for ancillary diagnostic studies and biomarker testing of therapeutic targets. This article summarizes recent advances in pleural effusion cytology, with a focus on the practical application of immunohistochemical markers, cytogenetic techniques, flow cytometry, and molecular techniques for the diagnosis and management of primary and secondary neoplasms of the pleura.

Keywords: Cytology; Effusion; Immunohistochemistry; Mesothelioma; Molecular.

Publication types

Review

MeSH terms

Biomarkers, Tumor / blood*
Cytodiagnosis / methods*
Cytodiagnosis / trends
GPI-Linked Proteins / blood*
Humans
Immunohistochemistry
Lung Neoplasms / blood
Lung Neoplasms / pathology
Mesothelioma / blood
Mesothelioma / pathology
Pleural Effusion / pathology*
Pleural Neoplasms / pathology*
Sensitivity and Specificity

Substances

Biomarkers, Tumor
GPI-Linked Proteins