Cryptococcal Meningitis and Tuberculous Meningitis Co-infection in HIV-Infected Ugandan Adults

Jayne Ellis; Fiona V Cresswell; Joshua Rhein; Kenneth Ssebambulidde; David R Boulware

doi:10.1093/ofid/ofy193

Cryptococcal Meningitis and Tuberculous Meningitis Co-infection in HIV-Infected Ugandan Adults

Open Forum Infect Dis. 2018 Aug 29;5(8):ofy193. doi: 10.1093/ofid/ofy193. eCollection 2018 Aug.

Authors

Jayne Ellis^{1

2}, Fiona V Cresswell^{1

3}, Joshua Rhein^{1

4}, Kenneth Ssebambulidde¹, David R Boulware⁴

Affiliations

¹ Infectious Diseases Institute, College of Health Sciences, Makerere University Kampala, Kampala, Uganda.
² Hospital for Tropical Diseases, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
³ Clinical Research Department, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom.
⁴ Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis.

Abstract

We report 5 HIV-infected Ugandan adults with cryptococcal and tuberculous (TB) meningitis co-infection. All unmasked meningitis occurred within 5 weeks of starting HIV therapy. Xpert MTB/RIF Ultra facilitated prompt diagnosis; however, 60% in-hospital mortality occurred. TB meningitis coinfection prevalence was 0.8% (5/586) among cryptococcal meningitis, 2 during second cryptococcal episodes.

Keywords: HIV/AIDS; case series; cryptococcal meningitis; tuberculosis; tuberculous meningitis.

Abstract

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