Gut dysbiosis, leaky gut, and intestinal epithelial proliferation in neurological disorders: towards the development of a new therapeutic using amino acids, prebiotics, probiotics, and postbiotics

Rev Neurosci. 2019 Jan 28;30(2):179-201. doi: 10.1515/revneuro-2018-0024.

Abstract

Here we offer a review of the evidence for a hypothesis that a combination of ingestible probiotics, prebiotics, postbiotics, and amino acids will help ameliorate dysbiosis and degeneration of the gut, and therefore promote restoration of nervous system function in a number of neurological indications.

Keywords: neurodegeneration; postbiotic; prebiotic; probiotic; therapeutic.

Publication types

  • Review

MeSH terms

  • Amino Acids / metabolism*
  • Animals
  • Dysbiosis / metabolism*
  • Gastrointestinal Microbiome / physiology*
  • Humans
  • Nervous System Physiological Phenomena
  • Prebiotics
  • Probiotics / metabolism*

Substances

  • Amino Acids
  • Prebiotics