Cantharidin is a highly potent toxin produced by insects belonging to the order Coleoptera and family Meloidae. The insecticidal activity of cantharidin against different orders of insects has been well documented. Although it is highly effective, its extraction and synthesis is very tedious. Consequently, much work is underway to synthesize the bioactive analogs of norcantharidin and study their relative structures. In this study, we investigate the acute and chronic toxicological effects of cantharidin and endothall, an analog of norcantharidin, using an age-stage-based two-sex life table methodology. Results reveal the acute toxicity of these compounds to Spodoptera litura Fabricius (Lepidoptera: Noctuidae), with the LC50 of cantharidin being 2.10 and endothall being 3.72 ppm, after 72 h posttreatment. Although both the compounds negatively affected the intrinsic rate of population increase (r), finite rate of increase (λ), net reproduction rate (R0), mean generation time (T), doubling time (DT), relative fitness (Rf), biotic potential, and longevity, cantharidin was slightly more effective. Among the reproductive parameters, fecundity was severely affected by cantharidin, which reduced offspring to 42 compared to 528 per female in the control cohort. Both cantharidin and endothall caused similar physiological changes such as weight reduction, wing malformation, and pupal deformities. These findings demonstrate that both cantharidin and endothall are highly toxic to S. litura, particularly in their chronic effects on population parameters. This will help us to understand the biological and ecological interactions in agricultural cropping systems and how their application will modify insect herbivory.