The Expanding Role of Systemic Therapy in the Management of Hepatocellular Carcinoma

Omar Abdel-Rahman; Winson Y Cheung

doi:10.1155/2018/4763832

The Expanding Role of Systemic Therapy in the Management of Hepatocellular Carcinoma

Can J Gastroenterol Hepatol. 2018 Aug 7:2018:4763832. doi: 10.1155/2018/4763832. eCollection 2018.

Authors

Omar Abdel-Rahman^{1

2}, Winson Y Cheung²

Affiliations

¹ Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
² Department of Oncology, University of Calgary, Tom Baker Cancer Centre, Calgary, Alberta, Canada.

Abstract

Hepatocellular carcinoma (HCC) represents a global health problem, with the majority of patients presenting at an advanced or incurable stage. The development of effective systemic therapy options for this disease has been challenging because many HCC patients suffer from underlying liver cirrhosis that precludes the safe delivery of systemic therapy. The current review seeks to provide an overview of the current systemic therapeutic approaches for advanced HCC as well as some of the novel management strategies that are currently being evaluated.

Publication types

Review

MeSH terms

Carcinoma, Hepatocellular / drug therapy*
Carcinoma, Hepatocellular / mortality
Carcinoma, Hepatocellular / pathology
Clinical Trials, Phase III as Topic
Female
Forecasting
Humans
Liver Neoplasms / drug therapy*
Liver Neoplasms / mortality
Liver Neoplasms / pathology
Male
Phenylurea Compounds / therapeutic use
Protein Kinase Inhibitors / therapeutic use*
Pyridines / therapeutic use
Risk Assessment
Sorafenib / therapeutic use
Survival Analysis
Treatment Outcome

Substances

Phenylurea Compounds
Protein Kinase Inhibitors
Pyridines
regorafenib
Sorafenib