This review focuses on the current knowledge of the effects of thyroid hormones on central nervous system differentiation and development in animals and the human fetal brain. The outcomes of children with congenital hypothyroidism and of newborns with hypothyroid pregnant mothers are emphasized, focusing on how therapies could affect and especially improve the outcomes.
Keywords: Congenital hypothyroidism; Fetal brain; Iodine insufficiency; Neurodevelopment; Thyroid hormones.
© 2018 S. Karger AG, Basel.