The Anticancer Effect of Sanguinarine: A Review

Curr Pharm Des. 2018;24(24):2760-2764. doi: 10.2174/1381612824666180829100601.

Abstract

In vitro and in vivo studies have revealed that Sanguinarine has antioxidant, anti-inflammatory, proapoptotic, and growth inhibitory effects on tumor cells of a variety of cancers. Previous research showed that sanguinarine induced apoptosis (cell death) and/or antiproliferative while reducing tumor cell antiangiogenic and anti-invasive properties. This paper describes various sanguinarine anti-cancer mechanisms, including inhibition of erroneously-activated signal transduction pathways, apoptosis, and tumor cell proliferation inhibition.

Keywords: Sanguinarine; anti-inflammatory; anti-tumor; apoptosis; cancer; pathways..

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Apoptosis / drug effects
  • Benzophenanthridines / pharmacology*
  • Cell Proliferation / drug effects
  • Humans
  • Isoquinolines / pharmacology*
  • Neoplasms / drug therapy*
  • Neoplasms / pathology
  • Signal Transduction / drug effects

Substances

  • Antineoplastic Agents, Phytogenic
  • Benzophenanthridines
  • Isoquinolines
  • sanguinarine