A novel HLA-A null allele, HLA-A*30:130N, discovered by amplicon-based next-generation sequencing

HLA. 2018 Nov;92(5):324-326. doi: 10.1111/tan.13385. Epub 2018 Oct 10.

Abstract

A novel HLA-A allele, HLA-A*30:130N, carrying a two-nucleotide insertion in exon 4 is described.

Keywords: frameshift mutation; next-generation sequencing; novel HLA-A null allele.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Blood Donors*
  • Exons*
  • Frameshift Mutation*
  • Genotype
  • HLA-A Antigens / genetics*
  • High-Throughput Nucleotide Sequencing / methods*
  • Histocompatibility Testing / methods*
  • Humans
  • Polymerase Chain Reaction / methods*
  • Sequence Analysis, DNA / methods
  • Sequence Homology

Substances

  • HLA-A Antigens
  • HLA-A*30 antigen