A novel HLA-B variant, HLA-B*14:02:16, discovered by amplicon-based next-generation sequencing

HLA. 2018 Nov;92(5):323-324. doi: 10.1111/tan.13384. Epub 2018 Oct 25.

Abstract

HLA-B*14:02:16 differs from B*14:02:01:01 by a synonymous nucleotide substitution in codon 141.

Keywords: next-generation sequencing; novel HLA-B allele; synonymous variation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Blood Donors*
  • Codon*
  • Genetic Variation*
  • Genotype
  • HLA-B14 Antigen / genetics*
  • Hematopoietic Stem Cell Transplantation*
  • High-Throughput Nucleotide Sequencing / methods*
  • Histocompatibility Testing / methods*
  • Humans
  • Male
  • Polymerase Chain Reaction
  • Sequence Analysis, DNA / methods
  • Sequence Homology
  • Silent Mutation

Substances

  • Codon
  • HLA-B*14:02 antigen
  • HLA-B14 Antigen