Loss of YTHDF2-mediated m6A-dependent mRNA clearance facilitates hematopoietic stem cell regeneration

Cell Res. 2018 Oct;28(10):1035-1038. doi: 10.1038/s41422-018-0082-y. Epub 2018 Aug 27.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Marrow Cells / cytology
  • Cell Proliferation / drug effects
  • Cell Proliferation / radiation effects
  • Cell Self Renewal / drug effects
  • Cell Self Renewal / radiation effects
  • Cells, Cultured
  • Fluorouracil / pharmacology
  • Hematopoietic Stem Cells / cytology
  • Hematopoietic Stem Cells / metabolism
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • RNA, Messenger / metabolism*
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism*
  • Radiation, Ionizing
  • Transcriptome / drug effects
  • Transcriptome / radiation effects

Substances

  • RNA, Messenger
  • RNA-Binding Proteins
  • YTHDF2 protein, mouse
  • Fluorouracil