Application of drug delivery systems for the controlled delivery of growth factors to treat nervous system injury

Fukai Ma; Fan Wang; Ronggang Li; Jianhong Zhu

doi:10.1080/15476278.2018.1491183

Application of drug delivery systems for the controlled delivery of growth factors to treat nervous system injury

Organogenesis. 2018;14(3):123-128. doi: 10.1080/15476278.2018.1491183. Epub 2018 Aug 27.

Authors

Fukai Ma¹, Fan Wang^{1

2}, Ronggang Li^{1

3}, Jianhong Zhu¹

Affiliations

¹ a Department of Neurosurgery , Fudan University Huashan Hospital and National Key Laboratory of Medical Neurobiology, the Institutes of Brain Science, Shanghai Medical College, Fudan University , Shanghai , China.
² b Department of Neurology , Guizhou Provincial People's Hospital , Guiyang , China.
³ c Department of Neurosurgery , Shanghai Public Health Clinical Center, Fudan University , Shanghai , China.

Abstract

Nervous system injury represent the most common injury and was unique clinical challenge. Using of growth factors (GFs) for the treatment of nervous system injury showed effectiveness in halting its process. However, simple application of GFs could not achieve high efficacy because of its rapid diffusion into body fluids and lost from the lesion site. The drug delivery systems (DDSs) construction used to deliver GFs were investigated so that they could surmount its rapid diffusion and retain at the injury site. This study summarizes commonly used DDSs for sustained release of GFs that provide neuroprotection or restoration effects for nervous system injury.

Keywords: drug delivery systems; growth factors; nervous system injury; neurogenesis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Biocompatible Materials
Delayed-Action Preparations / administration & dosage
Delayed-Action Preparations / therapeutic use
Drug Delivery Systems*
Humans
Immobilized Proteins / administration & dosage
Immobilized Proteins / therapeutic use
Intercellular Signaling Peptides and Proteins / administration & dosage*
Intercellular Signaling Peptides and Proteins / therapeutic use*
Trauma, Nervous System / drug therapy*

Substances

Biocompatible Materials
Delayed-Action Preparations
Immobilized Proteins
Intercellular Signaling Peptides and Proteins

Grants and funding

This work was supported by grants from MST (SQ2018YFA010113) and NSFC31771491, and grants (81471242, 81601069) from the National Nature Science Foundation and Ministry of Science and Technology of China.