Chronic Kidney Disease (CKD) is a globally public health problem taking into account its direct role in morbidity and mortality. The essential risk factors that contribute to the development and progression of CKD are hypertension, diabetes and dislipidemy. Besides hypertension, variations in blood pressure caused by baroreflex control dysfunction can lead to chronic kidney disease progression. The causes of impaired baroreflex dysfunction control in chronic kidney disease are not fully known. Understanding the mechanisms that contribute to increased blood pressure variability due to baroreflex dysfunction in chronic kidney disease may represent a key element in diminishing the physio pathological processes that contribute to the development and progression of renal injury.