Prospects of Noncoding RNAs in Hepatocellular Carcinoma

Huaixiang Zhou; Qiuran Xu; Chao Ni; Song Ye; Xiaowu Xu; Xiaoge Hu; Jiahong Jiang; Yeting Hong; Dongsheng Huang; Liu Yang

doi:10.1155/2018/6579436

Prospects of Noncoding RNAs in Hepatocellular Carcinoma

Biomed Res Int. 2018 Jul 26:2018:6579436. doi: 10.1155/2018/6579436. eCollection 2018.

Authors

Huaixiang Zhou^{1

2}, Qiuran Xu^{1

2}, Chao Ni^{1

3}, Song Ye⁴, Xiaowu Xu², Xiaoge Hu^{1

2}, Jiahong Jiang⁵, Yeting Hong⁶, Dongsheng Huang¹, Liu Yang^{1

2}

Affiliations

¹ Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, China.
² Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, China.
³ Department of General Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, China.
⁴ Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China.
⁵ Department of Second Clinical Medical College, Zhejiang Chinese Medicine University, Hangzhou, Zhejiang 310053, China.
⁶ Hangzhou Medical College, Hangzhou, Zhejiang 310014, China.

Abstract

Hepatocellular carcinoma (HCC) is a global health problem and one of the most common malignant tumors. Recent studies have shown that noncoding RNAs (ncRNAs) contribute to the pathogenesis of hepatocellular carcinoma (HCC). These RNAs may be involved in a variety of pathological processes such as cell proliferation, apoptosis, angiogenesis, invasion, and metastasis. In addition, abnormal expression of ncRNAs in HCC may provide potential prognostic or diagnostic biomarkers. This review provides an overview of the role and potential applications of ncRNAs, miRNAs, lncRNAs, circRNAs, and snoRNAs in liver cancer.

Publication types

Review

MeSH terms

Carcinoma, Hepatocellular* / diagnosis
Carcinoma, Hepatocellular* / therapy
Gene Expression Regulation, Neoplastic
Humans
Liver Neoplasms* / diagnosis
Liver Neoplasms* / therapy
Prognosis
RNA, Long Noncoding*
RNA, Untranslated

Substances

RNA, Long Noncoding
RNA, Untranslated