Soluble resistance-related calcium-binding protein in cancers

Abstract

Soluble resistance-related calcium binding protein (Sorcin) is an oncoprotein expressed at high levels in human cancers and confers multidrug resistance (MDR) in several tumors. Sorcin participates in a number of neoplastic processing including metastasis and apoptosis. In this review, we summarize and discuss the relationship of Sorcin with tumors as well as its regulatory mechanisms. Sorcin is increasingly considered as a potential molecular target for therapeutic intervention.

Keywords: Cancer; Metastasis; Multidrug-resistance (MDR); Soluble resistance-related calcium-binding protein (Sorcin).