Hydrophobic gating in BK channels

Nat Commun. 2018 Aug 24;9(1):3408. doi: 10.1038/s41467-018-05970-3.

Abstract

The gating mechanism of transmembrane ion channels is crucial for understanding how these proteins control ion flow across membranes in various physiological processes. Big potassium (BK) channels are particularly interesting with large single-channel conductance and dual regulation by membrane voltage and intracellular Ca2+. Recent atomistic structures of BK channels failed to identify structural features that could physically block the ion flow in the closed state. Here, we show that gating of BK channels does not seem to require a physical gate. Instead, changes in the pore shape and surface hydrophobicity in the Ca2+-free state allow the channel to readily undergo hydrophobic dewetting transitions, giving rise to a large free energy barrier for K+ permeation. Importantly, the dry pore remains physically open and is readily accessible to quaternary ammonium channel blockers. The hydrophobic gating mechanism is also consistent with scanning mutagenesis studies showing that modulation of pore hydrophobicity is correlated with activation properties.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Ion Channel Gating / physiology*
  • Large-Conductance Calcium-Activated Potassium Channels / chemistry*
  • Large-Conductance Calcium-Activated Potassium Channels / metabolism*
  • Potassium / metabolism
  • Protein Structure, Secondary

Substances

  • Large-Conductance Calcium-Activated Potassium Channels
  • Potassium