Ultrahigh efficient laser desorption ionization of saccharides by Ti-based metal-organic frameworks nanosheets

Abstract

We proposed some exfoliated Ti-based metal-organic frameworks (MOFs) nanosheets as matrices with ultrahigh ionization efficiency, free matrix background, significant dispersibility and acidic resistance. Combining the features between MOFs and 2-D nanomaterials, the NTU-9 nanosheets matrix also demonstrated suitable band gap energy and superior photoabsorption properties, much better than other representative MOFs. A wide range of small molecules that involving low mass region were also analyzed with NTU-9 nanosheets as the matrices in both positive-ion and negative-ion reflector modes. The ultra-efficient NTU-9 nanosheets matrix was successfully applied to serum for quantitative determination of glucose as a clinical diagnosis indicator of diabetes mellitus.

Keywords: Matrix; Metal-organic frameworks; Nanosheets; Saccharides.