Antioxidant activities of chitosans and its derivatives in in vitro and in vivo studies

Makoto Anraku; Janusz M Gebicki; Daisuke Iohara; Hisao Tomida; Kaneto Uekama; Toru Maruyama; Fumitoshi Hirayama; Masaki Otagiri

doi:10.1016/j.carbpol.2018.07.016

Antioxidant activities of chitosans and its derivatives in in vitro and in vivo studies

Carbohydr Polym. 2018 Nov 1:199:141-149. doi: 10.1016/j.carbpol.2018.07.016. Epub 2018 Jul 7.

Authors

Makoto Anraku¹, Janusz M Gebicki², Daisuke Iohara³, Hisao Tomida⁴, Kaneto Uekama⁵, Toru Maruyama⁶, Fumitoshi Hirayama³, Masaki Otagiri³

Affiliations

¹ Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan; DDS Research Institute, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan. Electronic address: anraku@ph.sojo-u.ac.jp.
² Department of Biological Sciences, Macquarie University, Sydney 2109, Australia.
³ Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan; DDS Research Institute, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.
⁴ Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Sanzo 1, Gakuen-cho, Fukuyama 729-0292, Japan.
⁵ Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.
⁶ Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.

PMID: 30143114
DOI: 10.1016/j.carbpol.2018.07.016

Abstract

This review focuses on the in vitro and in vivo antioxidant activities of various chitosan preparations, including those with different molecular weights and degrees of acetylation and the nanofibers produced from them. In in vitro studies, low molecular weight (LMW) chitosan with high degrees of deacetylation has more potent antioxidant properties than those of high molecular weight (HMW) chitosan. On the other hand, HMW chitosan has higher adsorption properties than those of LMW chitosan. On the basis of the in vitro results obtained, the ingestion of chitosan and nanofiber derived from it, with moderate MW and degrees of acetylation results in a significant reduction in oxidative stress in several chronic oxidative stress related diseases such as the metabolic syndrome and renal failure. In the future, chitosan and related nanofibers with presumed antioxidant properties may be used as a new source of antioxidant, as a possible food supplement, as an ingredient or in the pharmaceutical industry.

Keywords: Antioxidant; Chitosan; Nanofibers; Oxidative stress; Renal failure.

Publication types

Review