Molecularly endowed hydrogel with an in silico-assisted screened peptide for highly sensitive small molecule harvesting

Concetta Di Natale; Giorgia Celetti; Pasqualina Liana Scognamiglio; Chiara Cosenza; Edmondo Battista; Filippo Causa; Paolo A Netti

doi:10.1039/c8cc04943b

Molecularly endowed hydrogel with an in silico-assisted screened peptide for highly sensitive small molecule harvesting

Chem Commun (Camb). 2018 Sep 6;54(72):10088-10091. doi: 10.1039/c8cc04943b.

Authors

Concetta Di Natale¹, Giorgia Celetti, Pasqualina Liana Scognamiglio, Chiara Cosenza, Edmondo Battista, Filippo Causa, Paolo A Netti

Affiliation

¹ Center for Advanced Biomaterials for Healthcare, Istituto Italiano di Tecnologia (IIT), Largo Barsanti e Matteucci 53, Naples 80125, Italy.

PMID: 30116812
DOI: 10.1039/c8cc04943b

Abstract

We present a novel method for the detection of small molecules in complex fluids based on the selection of a specific peptide for target capture and its integration into an antifouling polymeric network. Such an approach can represent a universal platform for the direct and ultra-sensitive detection of small molecules in complex media.

MeSH terms

Aflatoxin M1 / analysis*
Aflatoxin M1 / chemistry
Amino Acid Sequence
Animals
Biosensing Techniques / methods*
Fluorescence
Hydrogels / chemistry*
Limit of Detection
Milk / chemistry
Molecular Dynamics Simulation
Oligopeptides / chemistry*
Peptide Library
Polyethylene Glycols / chemistry*

Substances

Hydrogels
Oligopeptides
Peptide Library
poly(ethylene glycol)diacrylate
Polyethylene Glycols
Aflatoxin M1