Coronary Artery Disease Severity Is Associated With Abdominal Aortic Intima-Media Thickness in Patients With Non-ST-Segment Elevation Myocardial Infarction

Angiology. 2019 Jul;70(6):561-566. doi: 10.1177/0003319718794833. Epub 2018 Aug 16.

Abstract

The aim of this study was to evaluate the relationship between aortic intima-media thickness (aIMT) and coronary artery disease (CAD) severity in patients with non-ST-segment elevation myocardial infarction (NSTEMI). SYNTAX score (SS) was calculated. Patients were categorized into 2 main groups according to the SS: patient with high risk (SS ≥ 13) and low risk (SS < 13). Common carotid artery IMT (cIMT), common femoral artery IMT, and aIMT were measured with a high-resolution ultrasound Doppler system. We had 147 (52.9%) patients in the high-risk group and 132 patients in the low-risk group. Both cIMT and aIMT were significantly increased, and left ventricular ejection fraction (LVEF) was significantly lower in the high-risk group; aIMT (odds ratio [OR]: 1.272, P < .001), cIMT (OR: 1.239, P = .009), and LVEF (OR: 0.931, P = .002) were determined as independent predictors for the high-risk group. When the cutoff value was accepted as 1.25 mm for the aIMT, patients with high SS identification had 74.1% sensitivity and 89.4% specificity (area under the curve: 0.764, P < .001). In conclusion, aIMT detected by abdominal B-mode ultrasonography is closely associated with CAD severity in patients with NSTEMI.

Keywords: aorta; coronary angiography; diagnostic ultrasound; intima-media thickness.

MeSH terms

  • Aged
  • Aorta, Abdominal / diagnostic imaging*
  • Coronary Angiography*
  • Coronary Artery Disease / diagnostic imaging*
  • Coronary Artery Disease / physiopathology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Non-ST Elevated Myocardial Infarction / diagnostic imaging*
  • Non-ST Elevated Myocardial Infarction / physiopathology
  • Predictive Value of Tests
  • Severity of Illness Index
  • Stroke Volume
  • Tunica Intima / diagnostic imaging*
  • Tunica Media / diagnostic imaging*
  • Ultrasonography, Doppler*
  • Ventricular Function, Left