Spontaneous Seroclearance of Hepatitis B Surface Antigen and Risk of Hepatocellular Carcinoma

Ci Song; Jian Zhu; Zijun Ge; Chengxiao Yu; Ting Tian; Hui Wang; Jing Han; Hongbing Shen; Juncheng Dai; Jianquan Lu; Zhibin Hu

doi:10.1016/j.cgh.2018.08.019

Spontaneous Seroclearance of Hepatitis B Surface Antigen and Risk of Hepatocellular Carcinoma

Clin Gastroenterol Hepatol. 2019 May;17(6):1204-1206. doi: 10.1016/j.cgh.2018.08.019. Epub 2018 Aug 13.

Authors

Ci Song¹, Jian Zhu², Zijun Ge¹, Chengxiao Yu¹, Ting Tian¹, Hui Wang¹, Jing Han³, Hongbing Shen¹, Juncheng Dai⁴, Jianquan Lu⁵, Zhibin Hu⁶

Affiliations

¹ Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.
² Qidong Liver Cancer Institute, The First People's Hospital of Qidong, China.
³ Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Epidemiology, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, China.
⁴ Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China. Electronic address: djc@njmu.edu.cn.
⁵ Qidong Liver Cancer Institute, The First People's Hospital of Qidong, China. Electronic address: jsqdlujj@sina.com.
⁶ Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China. Electronic address: zhibin_hu@njmu.edu.cn.

PMID: 30114488
DOI: 10.1016/j.cgh.2018.08.019

Abstract

Hepatitis B (HBV) infection is the leading cause of hepatocellular carcinoma (HCC) in Asia.¹ Hepatitis B surface antigen (HBsAg) seroclearance is considered to be one of the most important end points of chronic HBV infection and is associated with a reduced risk of HCC.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Biomarkers / blood
Carcinoma, Hepatocellular / diagnosis
Carcinoma, Hepatocellular / epidemiology
Carcinoma, Hepatocellular / etiology*
China / epidemiology
Female
Hepatitis B Surface Antigens / immunology*
Hepatitis B virus / immunology*
Hepatitis B, Chronic / complications*
Hepatitis B, Chronic / immunology
Humans
Incidence
Liver Neoplasms / diagnosis
Liver Neoplasms / epidemiology
Liver Neoplasms / etiology*
Male
Middle Aged
Prognosis
Risk Assessment / methods*
Risk Factors

Substances

Biomarkers
Hepatitis B Surface Antigens