Functional connectivity changes in the entorhinal cortex of taxi drivers

Abstract

Introduction: As a major interface between the hippocampus and the neocortex, the entorhinal cortex (EC) is widely known to play a pivotal role in spatial memory and navigation. Previous studies have suggested that the EC can be divided into the anterior-lateral (alEC) and the posterior-medial subregions (pmEC), with the former receiving object-related information from the perirhinal cortex and the latter receiving scene-related information from the parahippocampal cortex. However, the functional connectivity maps of the EC subregions in the context of extensive navigation experience remain elusive. In this study, we analyzed the functional connectivity of the EC in subjects with long-term navigation experience and aimed to find the navigation-related change in the functional properties of the human EC.

Methods: We investigated the resting-state functional connectivity changes in the EC subregions by comparing the EC functional connectivity maps of 20 taxi drivers with those of 20 nondriver controls. Furthermore, we examined whether the functional connectivity changes of the EC were related to the number of taxi driving years.

Results: Significantly reduced functional connectivity was found in the taxi drivers between the left pmEC and the right anterior cingulate cortex (ACC), right angular gyrus, and bilateral precuneus as well as some temporal regions, and between the right pmEC and the left inferior temporal gyrus. Notably, the strength of the functional connectivity between the left pmEC and the left precuneus, as well as the right ACC, was negatively correlated with the years of taxi driving.

Conclusion: This is the first study to explore the impact of long-term navigation experience on the connectivity patterns of the EC, the results of which may shed new light on the potential influence of extensive navigational training on the functional organization of the EC in healthy human brains.

Keywords: entorhinal cortex; fMRI; functional connectivity; navigation; resting-state.