Synthesis and DNA/RNA complementation studies of peptide nucleic acids containing 5-halouracils

Chun-Dong Liu; Jian-Hua Wang; Yang Xie; Hang Chen

doi:10.1039/c6md00536e

Synthesis and DNA/RNA complementation studies of peptide nucleic acids containing 5-halouracils

Medchemcomm. 2016 Dec 12;8(2):385-389. doi: 10.1039/c6md00536e. eCollection 2017 Feb 1.

Authors

Chun-Dong Liu¹, Jian-Hua Wang¹, Yang Xie¹, Hang Chen¹

Affiliation

¹ Key Laboratory of Biorheological Science and Technology , Ministry of Education , College of Bioengineering , Chongqing University , Chongqing , 400044 , China . Email: wjh@cqu.edu.cn ; ; Tel: +86 23 65102507.

Abstract

The monomers of peptide nucleic acids containing 5-halouracils (5-XU-PNA), incorporated into heptameric PNA in the middle position, have been synthesized. Thermodynamic analyses revealed that the heptameric PNA oligomer with DNA and RNA showed higher duplex stability compared to the unmodified PNA counterpart. NMR studies suggested that the electron withdrawing effect of the halogen atom increased the strength of the XU-A hydrogen bond.