Objective: To investigate the distribution and related factors of intraocular pressure (IOP) in the screened population aged over 50 years in Wenzhou. Methods: This study included 31 170 community residents aged 50 years or older in Wenzhou undergoing screening from March 2014 to January 2016. Participants underwent a complete ocular examination, including visual acuity, eye-ground photography, slit lamp and standardized measurement of IOP by non-contact tonometry. Subjects who had undergone ocular operation or laser peripheral iridectomy, had glaucoma, corneal or other ocular diseases that could possibly affect the IOP, had an IOP lower than 6 mmHg(1 mmHg=0.133 kPa) and visual acuity less than 0.3, or had monocular IOP values were excluded. The relationship between IOP and various parameters were analyzed. Results: A total of 20 875 subjects (6 902 males and 13 973 females) were enrolled in the current analysis, including 18 677 healthy persons and 2 125 glaucoma suspects, with an average age of (67.3±8.7) years old. The mean IOP (mean±standard deviation) of the healthy population was (13.5±3.0) mmHg (13.4±3.2) mmHg in right eyes and (13.6±3.3) mmHg in left eyes; 2.04% of the left eyes, 1.51% of the right eyes and 2.92% of either eyes of healthy population had an IOP >21 mmHg. The mean IOP in glaucoma suspects was significantly higher than that in the healthy population (P<0.001); 6.78% of the left eyes, 6.16% of the right eyes and 9.65% of either eyes of glaucoma suspects had an IOP >21 mmHg. Men had lower IOPs than women [healthy population: (12.9±3.2) mmHg versus (13.7±3.2) mmHg; P<0.05]. The linear function of IOP (Y) with age (X(1)) and the vertical cup disc ratio (X(2)) was ^Y=15.962-0.043X(1)+0.837X(2)(P<0.05) in the healthy population. Conclusion: The IOP among healthy persons aged over 50 years living in downtown Wenzhou was decreased with age but increased with the vertical cup disc ratio. The IOP in females was higher than that in males. About 3% of the healthy population had an IOP greater than 21 mmHg. (Chin J Ophthalmol, 2018, 54: 586-592).
目的： 探讨温州市社区50岁及以上筛查人群眼压的分布特征及其影响因素。 方法： 调查研究。于2014年3月至2016年1月在温州市区对31 170名50岁及以上的社区居民进行社区眼病筛查，包括生活视力、眼压、裂隙灯检查和眼底照相，眼压测量采用非接触眼压计。研究排除仅有单眼眼压数值者、眼压值低于6 mmHg（1 mmHg=0.133 kPa）且视力小于0.3者，排除有角膜疾患、内眼手术史、虹膜激光周边切除术后以及青光眼等患者。按照眼别、年龄、性别及视杯视盘直径比（C/D）进行分组分析。对双眼眼压相关性采用Pearson相关性分析，双眼眼压均值与年龄及垂直C/D进行回归方程计算，对各年龄组男女眼压差异比较采用两独立样本t检验，对各年龄组左右眼眼压比较采用配对t检验。 结果： 纳入研究者20 875人（男性6 902人，女性13 973人），其中健康人群为18 750人，可疑青光眼2 125人，年龄为（67.3±8.7）岁。健康人群双眼眼压为（13.5±3.0）mmHg[右眼眼压为（13.4±3.2）mmHg，左眼眼压为（13.6±3.3）mmHg]。左眼、右眼眼压>21 mmHg的比例分别为2.04%（381只眼）和1.52%（284只眼），任意一眼眼压>21 mmHg的比例为2.92%（545人）。可疑青光眼人群眼压高于健康人群（t=13.427，P<0.001)，可疑青光眼人群左眼、右眼眼压>21 mmHg的比例分别为6.78%（144只眼）和6.16%（131只眼），任意一眼眼压>21 mmHg的比例为9.65%（205人）。健康人群女性眼压[（12.8±3.2）mmHg]显著高于男性[（13.7±3.2）mmHg]（t=-16.878，P<0.001）。健康人群眼压（Y）与年龄（X(1)）、C/D（X(2)）的回归方程为^Y=15.962-0.043X(1)+0.837X(2)（F=107.751,P<0.001）。 结论： 温州市区50岁及以上健康人群的眼压值随年龄增加呈下降趋势，随C/D增加呈上升趋势,女性眼压高于的男性，约3%的健康人群眼压大于21 mmHg。（中华眼科杂志，2018，54：586-592）.
Keywords: Age factors; Aged; Community health services; Glaucoma; Intraocular pressure; Sex factors.