In vivo Evaluation of Anti-Hyperglycemic, Anti-hyperlipidemic and Anti-Oxidant Status of Liver and Kidney of Thymol in STZ-Induced Diabetic Rats

Bijan Ghorbanpour Oskouei; Soheil Abbaspour-Ravasjani; Seyed Jamal Musavinejad; Seyed Ahmad Salehzadeh; Alireza Abdolhosseinzadeh; Hamed Hamishehkar; Kazem Ghahremanzadeh; Behrooz Shokouhi

doi:10.1055/a-0646-3803

In vivo Evaluation of Anti-Hyperglycemic, Anti-hyperlipidemic and Anti-Oxidant Status of Liver and Kidney of Thymol in STZ-Induced Diabetic Rats

Drug Res (Stuttg). 2019 Jan;69(1):46-52. doi: 10.1055/a-0646-3803. Epub 2018 Aug 13.

Authors

Bijan Ghorbanpour Oskouei^{1

2}, Soheil Abbaspour-Ravasjani³, Seyed Jamal Musavinejad⁴, Seyed Ahmad Salehzadeh⁵, Alireza Abdolhosseinzadeh⁶, Hamed Hamishehkar⁴, Kazem Ghahremanzadeh⁷, Behrooz Shokouhi⁷

Affiliations

¹ Food and Drug Affairs, Tabriz University of Medical Science, Tabriz, Iran.
² Student Research Committee, Tabriz University of Medical Science, Tabriz, Iran.
³ Immology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
⁴ Islamic Azad University, Tabriz Branch, Faculty of Veterinary Medicine, Tabriz, Iran.
⁵ Department of Medicinal Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
⁶ Young Researchers and Elite Club, Bonab Branch, Islamic Azad university, Bonab, Iran.
⁷ Department of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran.

PMID: 30103218
DOI: 10.1055/a-0646-3803

Abstract

Aim: The evaluation of the positive and protective effects thymol as a natural compound on the STZ -induced diabetic rats.

Materials and methods: In this study, seven groups of the streptozotocin induced diabetic and normal rats (overall 42 males) were tested through various biochemical and histopathological factors such as: serum glucose, insulin, creatinine, lipids, lipoproteins, liver function-related enzymes, and antioxidant status in liver and kidney.

Results: The obtained results in this work indicated that thymol had a significant anti-hypoglycemic, anti-hypolipidemic activities on the STZ-induced diabetic rats. Further, the assessment different biochemical parameters revealed that the levels of creatinine, low-density lipoprotein cholesterol, very low density lipoprotein cholesterol, and liver function-related enzymes such as aspartate aminotransferase and alanine aminotransferase were decreased in the treated diabetes rats under 20 and 40 mg/kg thymol compared to the control diabetes group. Considerably, the anti-oxidant enzymes status that were achieved from the liver and kidney organs were modulated after treatment with thymol in the diabetic rats.

Conclusion: The results of this research has brough a new aspect concerning the proteevtive and positive effects of thymol on the diabetic complications in the animal model.