Targeting acute myeloid leukemia CD34+ stem/progenitor cells with small molecule inhibitor MK-8776

Leuk Res. 2018 Sep:72:71-73. doi: 10.1016/j.leukres.2018.08.003. Epub 2018 Aug 8.
No abstract available

Keywords: AML; Chk1; Leukemia stem cell; MK-8776.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD34* / genetics
  • Antigens, CD34* / metabolism
  • Drug Delivery Systems*
  • Female
  • Humans
  • Leukemia, Myeloid, Acute* / drug therapy
  • Leukemia, Myeloid, Acute* / genetics
  • Leukemia, Myeloid, Acute* / metabolism
  • Leukemia, Myeloid, Acute* / pathology
  • Male
  • Neoplasm Proteins* / genetics
  • Neoplasm Proteins* / metabolism
  • Neoplastic Stem Cells* / metabolism
  • Neoplastic Stem Cells* / pathology
  • Pyrazoles / pharmacology*
  • Pyrimidines / pharmacology*

Substances

  • Antigens, CD34
  • MK-8776
  • Neoplasm Proteins
  • Pyrazoles
  • Pyrimidines