Phosphorus binders: The new and the old, and how to choose

Arjun Sekar; Taranpreet Kaur; Joseph V Nally; Hernan Rincon-Choles; Stacey Jolly; Georges N Nakhoul

doi:10.3949/ccjm.85a.17054

Phosphorus binders: The new and the old, and how to choose

Cleve Clin J Med. 2018 Aug;85(8):629-638. doi: 10.3949/ccjm.85a.17054.

Authors

Arjun Sekar¹, Taranpreet Kaur², Joseph V Nally^{2

3}, Hernan Rincon-Choles^{2

4}, Stacey Jolly^{5

6}, Georges N Nakhoul^{7

4}

Affiliations

¹ Associates in Kidney Care, Des Moines, IA, USA. arjun_sekar@hotmail.com.
² Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH, USA.
³ Clinical Professor of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
⁴ Assistant Professor of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
⁵ Department of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA.
⁶ Associate Professor of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
⁷ Director, Center for Chronic Kidney Disease, Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH, USA.

PMID: 30102593
DOI: 10.3949/ccjm.85a.17054

Abstract

In caring for patients with chronic kidney disease, it is important to prevent and treat hyperphosphatemia with a combination of dietary restrictions and phosphorus binders. This review describes the pathophysiology and control of hyperphosphatemia and the different classes of phosphorus binders with respect to their availability, cost, side effects, and scenarios in which one class of binder may be more beneficial than another.

Publication types

Review

MeSH terms

Chelating Agents / therapeutic use*
Humans
Hyperphosphatemia / etiology
Hyperphosphatemia / physiopathology*
Phosphorus / blood*
Renal Dialysis / adverse effects
Renal Insufficiency, Chronic / blood*
Renal Insufficiency, Chronic / complications
Renal Insufficiency, Chronic / therapy

Substances

Chelating Agents
Phosphorus