Application of decellularized allograft for primary repair of congenital heart disease in Japan

Gen Thorac Cardiovasc Surg. 2019 Nov;67(11):976-978. doi: 10.1007/s11748-018-0988-9. Epub 2018 Aug 13.

Abstract

A 6-month-old infant with a double outlet right ventricle, doubly committed ventricular septal defect, and right ventricle outflow tract (RVOT) stenosis underwent intracardiac repair with RVOT reconstruction using a fresh decellularized allograft derived from a 1-year-old heart transplant recipient in Japan. Early postoperative evaluation via echocardiography and cardiac magnetic resonance imaging revealed that the pulmonary allograft and cardiac function were stable. This is the first case report on using a decellularized heart valve, which was resected from a heart transplant recipient, for primary repair of congenital heart disease in Japan.

Keywords: Congenital heart disease; Decellularization; Tissue engineering.

Publication types

  • Case Reports

MeSH terms

  • Allografts
  • Double Outlet Right Ventricle / surgery*
  • Female
  • Heart Septal Defects, Ventricular / surgery*
  • Humans
  • Infant
  • Japan
  • Male
  • Pulmonary Valve / transplantation*
  • Pulmonary Valve Stenosis / surgery*