The ethynylglycine synthon {(R)-2,2-dimethyl-3-(tert-butoxycarbonyl)-4-ethynyl-oxazolidine} is a chiral compound with valuable synthetic interest. An update (covering literature from 2005 to 2017) on the different synthetic utilities is reviewed and discussed.
Keywords: Cycloaddition; Ethynylglycine synthon; Metal-catalyzed coupling; Metallation; Synthesis; Terminal alkyne.