Measuring immune responses to pneumococcal vaccines

J Immunol Methods. 2018 Oct:461:37-43. doi: 10.1016/j.jim.2018.08.002. Epub 2018 Aug 8.

Abstract

Quantitative assays that measure immune response to pneumococcal vaccines are not only important for the evaluation of vaccine immunogenicity and efficacy, but are also utilized in the clinical diagnosis of immune deficiency syndromes. Analytical methods have progressed in order to meet changing demands in both of these areas, from early methods to ELISA, and most recently multiplex bead array assays and opsonophagocytosis assays (OPA). It is necessary to understand the evolution of such techniques and the criteria for their interpretation in order to better inform the application of currently available methods, and to guide future investigation into assay development.

Keywords: Immune deficiency; Immune response; Pneumococcal; Streptococcus pneumoniae; Vaccine.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adaptive Immunity*
  • Antibodies, Bacterial* / blood
  • Antibodies, Bacterial* / immunology
  • Enzyme-Linked Immunosorbent Assay / methods
  • Humans
  • Immunologic Deficiency Syndromes* / blood
  • Immunologic Deficiency Syndromes* / diagnosis
  • Immunologic Deficiency Syndromes* / immunology
  • Pneumococcal Vaccines* / immunology
  • Pneumococcal Vaccines* / therapeutic use

Substances

  • Antibodies, Bacterial
  • Pneumococcal Vaccines