Reaching the limit

Elife. 2018 Aug 10:7:e39804. doi: 10.7554/eLife.39804.

Authors

Benedetta Bolognesi^{1

2}, Ben Lehner^{1

3

4}

Affiliations

¹ Systems Biology Program, Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain.
² Institute of Bioengineering of Catalonia, Barcelona Institute of Science and Technology, Barcelona, Spain.
³ Universitat Pompeu Fabra, Barcelona, Spain.
⁴ Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain.

Abstract

How many copies of a protein can be made before it becomes toxic to the cell?

Keywords: S. cerevisiae; computational biology; glycolysis; overexpression; protein burden; systems biology.

© 2018, Bolognesi et al.

Publication types

Comment

MeSH terms

Gene Expression
Glycolysis*
Proteins / physiology*
Saccharomyces cerevisiae*
Systems Biology

Substances

Proteins