An alveolar recruitment maneuver followed by positive end-expiratory pressure improves lung function in healthy dogs undergoing laparoscopy

Caterina Di Bella; Luca Lacitignola; Salvatore Grasso; Paola Centonze; Antonella Greco; Rossella Ostuni; Antonio Crovace; Francesco Staffieri

doi:10.1016/j.vaa.2018.03.007

An alveolar recruitment maneuver followed by positive end-expiratory pressure improves lung function in healthy dogs undergoing laparoscopy

Vet Anaesth Analg. 2018 Sep;45(5):618-629. doi: 10.1016/j.vaa.2018.03.007. Epub 2018 Apr 16.

Authors

Caterina Di Bella¹, Luca Lacitignola², Salvatore Grasso³, Paola Centonze², Antonella Greco², Rossella Ostuni², Antonio Crovace², Francesco Staffieri⁴

Affiliations

¹ Department of Emergency and Organ Transplantation, "Aldo Moro" University of Bari, Bari, Italy.
² Department of Emergency and Organ Transplantation, Section of Veterinary Clinics and Animal Production, "Aldo Moro" University of Bari, Bari, Italy.
³ Department of Emergency and Organ Transplantation, Section of Anesthesia and Intensive Care, "Aldo Moro" University of Bari, Bari, Italy.
⁴ Department of Emergency and Organ Transplantation, Section of Veterinary Clinics and Animal Production, "Aldo Moro" University of Bari, Bari, Italy. Electronic address: francesco.staffieri@uniba.it.

PMID: 30093319
DOI: 10.1016/j.vaa.2018.03.007

Abstract

Objective: To evaluate the effects of an alveolar recruitment maneuver (ARM) followed by 5 cmH₂O positive end-expiratory pressure (PEEP) in dogs undergoing laparoscopy.

Study design: Prospective, randomized clinical study.

Animals: A group of 20 dogs undergoing laparoscopic ovariectomy.

Methods: Dogs were sedated with acepromazine and methadone intramuscularly; anesthesia was induced with propofol intravenously and maintained with inhaled isoflurane. The following baseline ventilatory setting (BVS) was administered: tidal volume of 12 mL kg^-1, inspiratory to expiratory ratio of 1:2, inspiratory pause 25% of inspiratory time, no PEEP and a respiratory rate to maintain end-tidal carbon dioxide tension between 5.3 and 7.3 kPa. Then, 10 minutes after the pneumoperitoneum, 10 dogs (RM) underwent a sustained inflation ARM followed by BVS plus 5 cmH₂O PEEP, while 10 dogs (NO-RM) were left with BVS throughout the procedure. Gas exchange and respiratory system mechanics were evaluated before the pneumoperitoneum (PPpre), before ARM (PP10), 30 minutes later (PP30) and 20 minutes after pneumoperitoneum discontinuation (PPpost20). Data were analyzed using anova (p < 0.05).

Results: The Fshunt at PP30 and PPpost20 was lower (p < 0.001) in the RM (2.3 ± 2.2 and 4.7 ± 3.7%) than in the NO-RM (5.2 ± 2.1 and 11.1 ± 5.2%), and PaO₂ at PP30 and PPpost20 was higher (p < 0.001) in the RM (67.3 ± 4.2 and 60.1 ± 9.4 kPa) than in the NO-RM (50.2 ± 7.4 and 45.5 ± 11.1 kPa). Static compliance of the respiratory system at PP30 and PPpost20 was greater (p < 0.001) in the RM (2.4 ± 0.2 and 2.1 ± 0.4 mL cmH₂O^-1 kg^-1) than in the NO-RM (0.9 ± 0.4 and 1.2 ± 0.2 mL cmH₂O^-1 kg^-1).

Conclusions and clinical relevance: In dogs undergoing laparoscopy, ARM followed by 5 cmH₂O PEEP improves gas exchange and respiratory system mechanics.

Keywords: alveolar recruitment; dog; laparoscopy; oxygenation.

MeSH terms

Anesthesia, General / methods
Anesthesia, General / veterinary
Animals
Dogs
Female
Laparoscopy / methods
Laparoscopy / veterinary*
Lung / physiology*
Ovariectomy / methods
Ovariectomy / veterinary*
Pneumoperitoneum, Artificial / methods
Pneumoperitoneum, Artificial / veterinary
Positive-Pressure Respiration / veterinary*
Pulmonary Gas Exchange / physiology
Respiration
Respiration, Artificial / methods
Respiration, Artificial / veterinary*