Clinical Manifestations and Bacterial Genomic Analysis of Group A Streptococcus Strains That Cause Pediatric Toxic Shock Syndrome

J Pediatric Infect Dis Soc. 2019 Jul 1;8(3):265-268. doi: 10.1093/jpids/piy069.

Abstract

We report here 18 cases of pediatric group A streptococcal toxic shock syndrome, associated clinical findings, and bacterial molecular genetic characteristics discovered through whole-genome sequencing. This comparative whole-genome sequencing revealed unique gene content (speK) and polymorphisms (dpiB) in emm87 group A Streptococcus, the relative contributions of which, in combination with the host response, in the development of streptococcal toxic shock syndrome remain to be elucidated.

Keywords: emm type; STSS; group A Streptococcus; invasive; shock.

MeSH terms

  • Antigens, Bacterial / blood
  • Antigens, Bacterial / genetics
  • Bacterial Outer Membrane Proteins / genetics
  • Child
  • Child, Preschool
  • Female
  • Genes, Bacterial / genetics*
  • Genotyping Techniques
  • Humans
  • Male
  • Phylogeny
  • Polymorphism, Single Nucleotide
  • Retrospective Studies
  • Shock, Septic / microbiology*
  • Streptococcal Infections / microbiology*
  • Streptococcus pyogenes / genetics*
  • Whole Genome Sequencing

Substances

  • Antigens, Bacterial
  • Bacterial Outer Membrane Proteins