Endoglin Targeting in Colorectal Tumor Microenvironment

Clin Cancer Res. 2018 Dec 15;24(24):6110-6111. doi: 10.1158/1078-0432.CCR-18-2023. Epub 2018 Aug 3.

Abstract

On endothelial cells, the TGFβ/BMP-9 coreceptor, endoglin, emerged as a promising antiangiogenic target in colorectal cancer. Its promiscuous expression by cancer-associated fibroblasts (CAF) emerges to facilitate metastasis. The multitarget impact of neutralizing endoglin may offer added benefit in controlling colorectal cancer.See related article by Paauwe et al., p. 6331.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Antigens, CD
  • Cancer-Associated Fibroblasts*
  • Colorectal Neoplasms*
  • Endoglin
  • Endothelial Cells
  • Humans
  • Receptors, Cell Surface
  • Tumor Microenvironment

Substances

  • Antigens, CD
  • Endoglin
  • Receptors, Cell Surface