Intestinal Crypts Assume the Fetal Position in Response to Injury

Adam R Pont; Kelley S Yan

doi:10.1016/j.stem.2018.07.013

Intestinal Crypts Assume the Fetal Position in Response to Injury

Cell Stem Cell. 2018 Aug 2;23(2):158-159. doi: 10.1016/j.stem.2018.07.013.

Authors

Adam R Pont¹, Kelley S Yan²

Affiliations

¹ Columbia Center for Human Development, Columbia Stem Cell Initiative, Department of Medicine, Division of Digestive and Liver Diseases, and Department of Genetics & Development, Columbia University Medical Center, New York, NY 10032, USA.
² Columbia Center for Human Development, Columbia Stem Cell Initiative, Department of Medicine, Division of Digestive and Liver Diseases, and Department of Genetics & Development, Columbia University Medical Center, New York, NY 10032, USA. Electronic address: ky2004@cumc.columbia.edu.

PMID: 30075126
DOI: 10.1016/j.stem.2018.07.013

Abstract

Distinct stem/progenitor cells generate intestinal epithelium during fetal and postnatal life. In a recent issue of Nature, Nusse and Savage et al. use helminth infection to show that Lgr5⁺ intestinal stem cells are replaced by fetal-like progenitors following injury, suggesting that some fetal developmental pathways are repurposed during injury-induced tissue regeneration.

Publication types

Comment

MeSH terms

Animals
Helminths*
Intestinal Mucosa
Intestines
Regeneration
Stem Cell Niche*
Stem Cells

Abstract

Publication types

MeSH terms

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