Abstract
Chemically incorporating Schiff base interactions into silicate frameworks endows the obtained mesoporous organosilica based drug carriers with ultrafast pH-responsive degradability and efficient anti-cancer drug release kinetics, resulting in enhanced cancer therapy.
MeSH terms
-
Animals
-
Antineoplastic Agents / therapeutic use*
-
Doxorubicin / analogs & derivatives*
-
Doxorubicin / therapeutic use
-
Drug Carriers / chemical synthesis
-
Drug Carriers / chemistry*
-
Drug Liberation
-
Humans
-
Hydrogen-Ion Concentration
-
Kinetics
-
Mice, Inbred BALB C
-
Nanoparticles / chemistry*
-
Organosilicon Compounds / chemistry*
-
Particle Size
-
Polyethylene Glycols / therapeutic use
-
Porosity
-
Schiff Bases / chemical synthesis
-
Schiff Bases / chemistry*
-
Xenograft Model Antitumor Assays
Substances
-
Antineoplastic Agents
-
Drug Carriers
-
Organosilicon Compounds
-
Schiff Bases
-
liposomal doxorubicin
-
Polyethylene Glycols
-
Doxorubicin