Marine-derived Trichoderma Species as a Promising Source of Bioactive Secondary Metabolites

Mini Rev Med Chem. 2018;18(20):1702-1713. doi: 10.2174/1389557518666180727130826.

Abstract

Marine-derived fungi Trichoderma genus are serving as a valuable resource for structurally novel natural products encompassing a variety of chemical substances and diverse pharmacological applications. So far, about 78 metabolites have been structurally documented from the species of marine Trichoderma genus and a large proportion of these metabolites exhibited therapeutic properties with potential application in drug discovery. This mini-review focuses on the structures and bioactivities of these secondary metabolites from marine-derived Trichoderma species.

Keywords: Aspergillus; Secondary metabolites; Trichoderma; alkaloids; bioactivity; marine fungi..

Publication types

  • Review

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification
  • Alkaloids / pharmacology
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / isolation & purification
  • Anti-Infective Agents / pharmacology
  • Cell Survival / drug effects
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / metabolism
  • Fungi / drug effects
  • Humans
  • Monophenol Monooxygenase / antagonists & inhibitors
  • Monophenol Monooxygenase / metabolism
  • Seawater / microbiology*
  • Staphylococcus aureus / drug effects
  • Trichoderma / chemistry
  • Trichoderma / metabolism*

Substances

  • Alkaloids
  • Anti-Infective Agents
  • Enzyme Inhibitors
  • Monophenol Monooxygenase