Control of Inflammasome Activation by Phosphorylation

Tao Gong; Wei Jiang; Rongbin Zhou

doi:10.1016/j.tibs.2018.06.008

Control of Inflammasome Activation by Phosphorylation

Trends Biochem Sci. 2018 Sep;43(9):685-699. doi: 10.1016/j.tibs.2018.06.008. Epub 2018 Jul 23.

Authors

Tao Gong¹, Wei Jiang², Rongbin Zhou³

Affiliations

¹ Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China; Department of Immunology, Anhui Provincial Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui 233030, People's Republic of China.
² Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China. Electronic address: ustcjw@ustc.edu.cn.
³ Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China; Innovation Center for Cell Signaling Network, University of Science and Technology of China, Hefei 230027, China; CAS Centre for Excellence in Cell and Molecular Biology, University of Science and Technology of China, Hefei 230027, China. Electronic address: zrb1980@ustc.edu.cn.

PMID: 30049633
DOI: 10.1016/j.tibs.2018.06.008

Abstract

Inflammasomes are cytosolic protein complexes composed of innate immune sensors, the adaptor protein ASC, and the cysteine protease caspase-1. In response to microbial infection or 'danger signals', inflammasomes play critical roles in host defense or contribute to the pathogenesis of various inflammatory diseases. Recent studies have provided abundant evidence for a vital role of phosphorylation in the regulation of inflammasome assembly and activation. This review integrates previous observations and discoveries for inflammasome regulation by protein phosphorylation with the most recent findings. Additionally, the timely application and clinical prospects in the treatment of inflammatory diseases, by targeting related protein kinases or phosphatases, are also discussed.

Keywords: Inflammasome; kinase inhibitors; phosphorylation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Caspase 1 / metabolism
Humans
Infections / metabolism*
Infections / pathology
Inflammasomes / metabolism*
Inflammation / pathology
Phosphoprotein Phosphatases / metabolism*
Phosphorylation
Protein Kinases / metabolism*
Signal Transduction*

Substances

Inflammasomes
Protein Kinases
Phosphoprotein Phosphatases
Caspase 1