Epitranscriptomes in the Adult Mammalian Brain: Dynamic Changes Regulate Behavior

Neuron. 2018 Jul 25;99(2):243-245. doi: 10.1016/j.neuron.2018.07.019.

Abstract

Epitranscriptomic modification of mRNA affects its metabolism and has recently been shown to regulate brain development. Two studies in this issue of Neuron, Koranda et al. (2018) and Engel et al. (2018), uncover dynamic and critical roles of m6A/m RNA modifications in the adult mammalian brain in regulating physiological and stress-induced behaviors.

Keywords: FTO; Mettl14; Mettl3; N(6)-methyladenosine (m(6)A); behavior; epitranscriptomics; gene expression; stress.

Publication types

  • Comment

MeSH terms

  • Adenosine*
  • Animals
  • Brain
  • Methylation
  • Methyltransferases*
  • RNA, Messenger

Substances

  • RNA, Messenger
  • Methyltransferases
  • Adenosine