TanCAR T cells targeting CD19 and CD133 efficiently eliminate MLL leukemic cells

Leukemia. 2018 Sep;32(9):2012-2016. doi: 10.1038/s41375-018-0212-z. Epub 2018 Jul 25.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • AC133 Antigen / immunology*
  • Animals
  • Antigens, CD19 / immunology*
  • Biomarkers
  • Cell Line, Tumor
  • Cells, Cultured
  • Cytotoxicity, Immunologic
  • Disease Models, Animal
  • Histone-Lysine N-Methyltransferase / genetics*
  • Humans
  • Immunophenotyping
  • Immunotherapy, Adoptive*
  • Leukemia, Biphenotypic, Acute / genetics
  • Leukemia, Biphenotypic, Acute / immunology
  • Leukemia, Biphenotypic, Acute / metabolism
  • Leukemia, Biphenotypic, Acute / therapy
  • Mice
  • Myeloid-Lymphoid Leukemia Protein / genetics*
  • Receptors, Antigen, T-Cell / genetics
  • Receptors, Antigen, T-Cell / metabolism*
  • Receptors, Chimeric Antigen / genetics
  • Receptors, Chimeric Antigen / metabolism*
  • T-Cell Antigen Receptor Specificity
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / metabolism*
  • Xenograft Model Antitumor Assays

Substances

  • AC133 Antigen
  • Antigens, CD19
  • Biomarkers
  • KMT2A protein, human
  • Receptors, Antigen, T-Cell
  • Receptors, Chimeric Antigen
  • Myeloid-Lymphoid Leukemia Protein
  • Histone-Lysine N-Methyltransferase