Enzymatic Formation of Oxygen-Containing Heterocycles in Natural Product Biosynthesis

Song Meng; Gong-Li Tang; Hai-Xue Pan

doi:10.1002/cbic.201800225

Enzymatic Formation of Oxygen-Containing Heterocycles in Natural Product Biosynthesis

Chembiochem. 2018 Oct 4;19(19):2002-2022. doi: 10.1002/cbic.201800225. Epub 2018 Aug 21.

Authors

Song Meng¹, Gong-Li Tang¹, Hai-Xue Pan¹

Affiliation

¹ State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, University of the Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.

PMID: 30039582
DOI: 10.1002/cbic.201800225

Abstract

Oxygen-containing heterocycles are widely encountered in natural products that display diverse pharmacological properties and have potential benefits to human health. The formation of O-heterocycles catalyzed by different types of enzymes in the biosynthesis of natural products not only contributes to the structural diversity of these compounds, but also enriches our understanding of nature's ability to construct complex molecules. This minireview focuses on the various modes of enzymatic O-heterocyclization identified in natural product biosynthesis and summarizes the possible mechanisms involved in ring closure.

Keywords: biosynthesis; cyclization; natural products; oxygen heterocycles; oxygenation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biological Products / metabolism*
Catalysis
Cyclization
Enzymes* / chemistry
Enzymes* / metabolism
Heterocyclic Compounds / metabolism*
Oxygen / metabolism*

Substances

Biological Products
Enzymes
Heterocyclic Compounds
Oxygen