Reactions in NMR Tubes as Key Weapon in Rational Drug Design

Dimitrios Ntountaniotis

doi:10.1007/978-1-4939-8630-9_25

Reactions in NMR Tubes as Key Weapon in Rational Drug Design

Methods Mol Biol. 2018:1824:417-430. doi: 10.1007/978-1-4939-8630-9_25.

Author

Dimitrios Ntountaniotis¹

Affiliation

¹ Department of Chemistry, Laboratory of Organic Chemistry, National and Kapodistrian University of Athens, Athens, Greece. doudaniotis@yahoo.gr.

PMID: 30039422
DOI: 10.1007/978-1-4939-8630-9_25

Abstract

NMR spectroscopy is a powerful technique suitable for obtaining detailed structural and dynamic data at atomic resolution. Progress in NMR instrumentation has led the scientific community to produce novel techniques which provide valuable information to resolve demanding and crucial questions of molecular biology and rational drug design. This chapter outlines the progress of NMR spectroscopy in the rational drug design. In addition, it offers an example of a reaction in NMR tube for achieving rational drug design.

Keywords: Drug design and discovery; NMR spectroscopy for liquids; Structural properties.

MeSH terms

Drug Design
Drug Discovery / methods*
Imidazoles / chemistry*
Nuclear Magnetic Resonance, Biomolecular / methods*
Tetrazoles / chemistry*

Substances

Imidazoles
Tetrazoles
olmesartan