Artificial vesicles can aid in the study and understanding of biological cell membranes. This study employs pnictogen bonding to actively direct the self-assembly of a true reversed bilayer. Antimony(iii) alkoxide cages that self-assemble through multiple strong SbO interactions propagate in two dimensions to form a reverse bilayer structure in the solid state. Long alkyl tails allow these reverse bilayers to be processed into vesicles in solution that are a reverse of biological cell membranes.