Background: The preferred therapy for patients with pulmonary nodules which highly suspected as lung cancer by low-dose spiral computed tomography (CT) is surgery, but the best screening method of whole body is not clear yet. The aim of this study is to investigate the differences in the progression-free survival (PFS) of patients with Ia stage non-small cell lung cancer after screening of positron emission computed tomography (PET)-CT and conventional imaging (B-ultrasound/CT/MRI/ECT, BCME).
Methods: A total of 300 cases of Ia stage non-small cell lung cancer were collected, of which 170 cases were performed PET-CT and 130 cases were performed BCME before operation. The basic characteristics of the two groups were analyzed by propensity score matching (PSM), and 114 cases of each group were included in the study. The survival analysis was carried out by the Kaplan-Meier survival curve and the Cox regression analysis.
Results: There was no significant difference between each group analyzed by PSM. The PFS of PET-CT and BCME were (44.9±27.2) months and (44.1±33.1) months (χ2=1.284, P=0.257). Both of the method ssucceed in screening. It is not the PFS influence factors. The false positive of PET-CT and BCME were 10 cases and 8 cases (χ2=0.241, P=0.623).
Conclusions: Both PET-CT and BCME can be used as a screening method for Ia stage non-small cell lung cancer according to individualized choice of patients.
【中文题目：18F-PET-CT是Ia期非小细胞肺癌术前筛查 首选吗？】 【中文摘要：背景与目的 低剂量螺旋计算机断层扫描（computed tomography, CT）筛查高度怀疑为肺癌的肺部阳性结节者，首选外科治疗。在实施外科治疗前如何选择全身筛查方式目前尚不清，本研究旨在探讨采用正电子发射型计算机断层显像（positron emission computed tomography, PET-CT）和常规影像（B-ultrasound/CT/MRI/ECT, BCME）对Ia期非小细胞肺癌（non-small cell lung cancer, NSCLC）术前筛查后患者的无疾病进展期（progression-free survival, PFS）是否存在差异。方法 回顾性收集170例术前PET-CT筛查和130例BCME筛查的Ia期NSCLC患者，将两组临床基本特征进行倾向值匹配分析（propensity score matching, PSM），两组分别有114例纳入研究。采用Kaplan-Meier生存曲线和Cox回归分析进行生存分析。结果 经PSM匹配后两组临床基本特征无显著差异。PET-CT组和BCME组的PFS分别为（44.9±27.2）个月、（44.1±33.1）个月，无显著差异（χ2=1.284, P=0.257）。PET-CT组术前筛查假阳性10例，BCME组8例，二者筛查假阳性率无显著差异（χ2=0.241, P=0.623），两种方式均能达到筛查目的，不是PFS的影响因素。结论 PET-CT和BCME均可用于Ia期NSCLC根治术前筛查，可根据患者实际情况进行个体化选择。 】 【中文关键词：肺肿瘤；PET-CT；无疾病进展期】.
Keywords: Lung neoplasms; PET-CT; Progression-free survival.