Rituximab primarily targets an intra-clonal BCR signaling proficient CLL subpopulation characterized by high CD20 levels

Leukemia. 2018 Sep;32(9):2028-2031. doi: 10.1038/s41375-018-0211-0. Epub 2018 Jul 20.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibody-Dependent Cell Cytotoxicity / immunology
  • Antigens, CD20 / metabolism*
  • Antineoplastic Agents, Immunological / pharmacology*
  • Antineoplastic Agents, Immunological / therapeutic use
  • Biomarkers
  • Complement System Proteins / immunology
  • Cytotoxicity, Immunologic
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy
  • Leukemia, Lymphocytic, Chronic, B-Cell / immunology
  • Leukemia, Lymphocytic, Chronic, B-Cell / metabolism*
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology
  • Phenotype
  • Receptors, Antigen, B-Cell / metabolism*
  • Rituximab / pharmacology*
  • Rituximab / therapeutic use
  • Signal Transduction / drug effects*
  • Tumor Cells, Cultured
  • Tumor Microenvironment / drug effects
  • Tumor Microenvironment / immunology

Substances

  • Antigens, CD20
  • Antineoplastic Agents, Immunological
  • Biomarkers
  • Receptors, Antigen, B-Cell
  • Rituximab
  • Complement System Proteins