Lutescins A and B, two new ellagitannins from the twigs of Trigonostemon lutescens and their antiproliferative activity

Chang-Shui Yang; Tong Zhou; Su-Qiao Han; Xing Wang; Xiao-Yun Dong; Ping Bo

doi:10.1016/j.fitote.2018.07.008

Lutescins A and B, two new ellagitannins from the twigs of Trigonostemon lutescens and their antiproliferative activity

Fitoterapia. 2018 Oct:130:31-36. doi: 10.1016/j.fitote.2018.07.008. Epub 2018 Jul 17.

Authors

Chang-Shui Yang¹, Tong Zhou², Su-Qiao Han², Xing Wang², Xiao-Yun Dong³, Ping Bo⁴

Affiliations

¹ Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225001, China; Jiangsu Key Laboratory of Integrated Traditional CHINESE and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University, Yangzhou 225001, China; The Key Laboratory of Syndrome Differentiation and Treatment of Gastric Cancer of the State Administration of Traditional Chinese Medicine, Yangzhou 225001, China.
² Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225001, China.
³ Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225001, China; Jiangsu Key Laboratory of Integrated Traditional CHINESE and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University, Yangzhou 225001, China. Electronic address: xiaoyundong@yahoo.com.
⁴ Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225001, China; Jiangsu Key Laboratory of Integrated Traditional CHINESE and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University, Yangzhou 225001, China.

PMID: 30025799
DOI: 10.1016/j.fitote.2018.07.008

Abstract

Two new ellagitannins, lutescins A and B (1-2), along with eight known compounds (3-10), were isolated from the twigs of Trigonostemon lutescens. Their structures were elucidated by extensive spectroscopic analyses as well as by comparison with literature data. Compounds 1 and 2 are the first examples of ellagitannins reported in Trigonostemon Genus, and their structures featured a hexahydroxydiphenoyl (HHDP) moiety less often as R configurations in natural products. In addition, all isolated compounds were tested for their inhibitory effects against HeLa, HCT116 and HepG2 cancer cell lines. Compounds 1, 2, 5 showed potent antiproliferative activity, compared with the positive control Cisplatin.

Keywords: Antiproliferative activity; Ellagitannin; Lutescin; Trigonostemon lutescens.

MeSH terms

Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Cell Line, Tumor
China
Euphorbiaceae / chemistry*
Humans
Hydrolyzable Tannins / isolation & purification*
Hydrolyzable Tannins / pharmacology
Molecular Structure
Phytochemicals / isolation & purification*
Phytochemicals / pharmacology

Substances

Antineoplastic Agents, Phytogenic
Hydrolyzable Tannins
Phytochemicals