Background: Off state toe dystonia (TD) is a symptom frequently encountered in Parkinson's disease (PD), but little is known about its evolution after subthalamic nucleus deep brain stimulation (STN-DBS).
Objective: To analyze the prevalence and the evolution of TD in PD patients candidate to STN-DBS.
Methods: Individual data of consecutive 130 PD patients who underwent STN-DBS between 2010 and 2015 were collected.
Results: Data were successfully collected in 95 patients. TD affect 45.3% of the patients in our cohort. TD was present in 32.7% of patients before surgery and was alleviated by STN-DBS in 48% of the cases. Motor improvement provided by STN-DBS, levodopa-equivalent treatment diminution after surgery, disease duration or age at the time of surgery were not predictive of TD evolution. A younger age at PD diagnosis was significantly associated with TD resolution.
Conclusion: STN-DBS is partially efficient for TD but its evolution seems independent of significant predictive factors.
Keywords: Deep brain stimulation; Levodopa induced dyskinesia; Parkinson's disease; Subthalamic nucleus; Toe dystonia.
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