Synthesis of a Biologically Important Adenosine Triphosphate Analogue, ApppD

Petri A Turhanen

doi:10.1021/acsomega.7b00531

Synthesis of a Biologically Important Adenosine Triphosphate Analogue, ApppD

ACS Omega. 2017 Jun 30;2(6):2835-2838. doi: 10.1021/acsomega.7b00531. Epub 2017 Jun 21.

Author

Petri A Turhanen¹

Affiliation

¹ School of Pharmacy, Biocenter Kuopio, University of Eastern Finland, P.O. Box 1627, FIN-70211 Kuopio, Finland.

Abstract

The chemical synthesis of a adenosine triphosphate analogue, 1-adenosin-5'-yl 3-(3-methylbut-2-enyl) triphosphoric acid diester (ApppD), is described. ApppD is known to be an active metabolite of the mevalonate pathway in the human body like its structural isomer isopentenyl ester of ATP (ApppI). Very recently, ApppI has been found to possess novel function(s); now it will also be possible to examine the effects of ApppD more precisely because it can be synthesized in reasonable amounts. 1-Adenosin-5'-yl 3-(3-methylbut-2-enyl) diphosphoric acid diester (AppD; a adenosine diphosphate analogue) was also isolated from the synthesis mixture. Both ApppD and AppD were characterized by ¹H, ¹³C, ³¹P NMR and mass spectrometry methods.