Intestinal Tolerance, with a Little Help from Our Microbial Friends

Hélène Descamps; Christoph A Thaiss

doi:10.1016/j.immuni.2018.06.015

Intestinal Tolerance, with a Little Help from Our Microbial Friends

Immunity. 2018 Jul 17;49(1):4-6. doi: 10.1016/j.immuni.2018.06.015.

Authors

Hélène Descamps¹, Christoph A Thaiss²

Affiliations

¹ Microbiology Department and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
² Microbiology Department and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: thaiss@pennmedicine.upenn.edu.

PMID: 30021145
DOI: 10.1016/j.immuni.2018.06.015

Abstract

The intestinal immune system performs a tightrope walk between anti-pathogen immunity and tolerance to innocuous luminal antigens. In this issue of Immunity, Kim et al. (2018) demonstrate that the microbiota is driving tolerance to food antigens and dampening inflammatory responses through CX₃CR1⁺ mononuclear phagocytes.

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MeSH terms

Friends*
Intestines
Microbiota
Phagocytes
T-Lymphocytes*