Hitting HIV's Harpoon

Marit J van Gils; Rogier W Sanders

doi:10.1016/j.immuni.2018.07.003

Hitting HIV's Harpoon

Immunity. 2018 Jul 17;49(1):14-15. doi: 10.1016/j.immuni.2018.07.003.

Authors

Marit J van Gils¹, Rogier W Sanders²

Affiliations

¹ Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands. Electronic address: m.j.vangils@amc.uva.nl.
² Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA. Electronic address: r.w.sanders@amc.uva.nl.

PMID: 30021141
DOI: 10.1016/j.immuni.2018.07.003

Abstract

The HIV-1 fusion peptide is a target for broadly neutralizing antibodies. In a recent issue of Nature Medicine, Xu et al. (2018) provide proof-of-concept that vaccination with fusion peptide followed by vaccination with an envelope glycoprotein trimer can induce antibodies in animal models that neutralize diverse HIV-1 viruses.

Publication types

Comment

MeSH terms

AIDS Vaccines
Animals
Antibodies, Neutralizing
Epitopes
HIV Antibodies
HIV Infections*
HIV-1 / immunology*
Peptides

Substances

AIDS Vaccines
Antibodies, Neutralizing
Epitopes
HIV Antibodies
Peptides